부신기능저하증 증상It can be broadly divided into primary adrenal insufficiency and secondary adrenal insufficiency. Primary adrenal insufficiency
(Primary adrenal insufficiency: Addison’s disease)
Secondary adrenal insufficiency
Clinical findings
Laboratory findings
Findings due to glucocorticoid (cortisol) deficiency
Findings due to mineralocorticoid deficiency
(Only occurs in primary adrenal insufficiency)
Findings due to androgen deficiency
Other findings
Findings due to ACTH excess
① In the past, 70-90% of cases were caused by tuberculosis, and in developing countries, tuberculosis is still the main cause
Comparison of clinical features between primary adrenal insufficiency and secondary adrenal insufficiency
Primary adrenal insufficiency
Secondary Hypoadrenal insufficiency
Occurrence site
Adrenal
Hypothalamus-pituitary
ACTH
Elevated
Decreased
Skin opacity
Increased
Decreased
Weight
Weight loss
Various aspects
GH/gonadotropins
No change
Decreased
Mineralocorticoid
Deficiency
Normal
Response to ACTH administration
No response
Sluggish response
Chronic adrenal insufficiency
↔
Acute adrenal insufficiency
References
